Daily Speculations

 

Comments on our May 29, 2003, column, “A 12-stock strategy for the biotech boom

 

- and -

 

Full remarks by Roger Longman, our source for the column.

 

 

 

Bill Egan:

Subject: [SPEC-LIST] biotech insider buying

Date: 05/25/2003 10:39:25

 

How many of these insider buys were done by people new to the company? At a

number of companies, it is expected that higher level new hires purchase

some stock when they join. The quality of the buy signal then has little to

do with the insider expecting the stock to outperform because new hires are

not yet privy to all the internal information of the company.

 

Conversely, an insider who has been at the company for a few years and

is buying sends a more significant signal. A larger amount also has more meaning.

 

PCOP reports tiny 401K/ESPP purchases (less than 100 shares at a time) as

"insider buys" but there are also some purchases in the thousands of shares.

401(k) purchases have the tax incentive, and ESPP buys generally have an

automatic 15% discount to market, and present an arbitrage opportunity every

six months (get stock 15% less than lowest price of beginning and end of period,

and sell the instant you acquire). For ARQL, one fund, a "beneficial owner," has

been buying, but real insiders other than one director, have not.

 

Most companies in biotech issue options, so if an actual employee who has been

around for a few years buys, that really means something. Director types

are next best, I think. CRGN represents an interesting mix of two of these:

Rothberg, the Chairman and CEO, is buying a lot, but he founded the company

and therefore may have an issue with pride.

 

It might be beneficial for you to go back and categorize the number of

buyers, types of buyers, and amounts of stock they bought and see if any

signal rises above the noise.

 

Bill Egan is a PhD research scientist working in the pharmaceuticals industry.

 

 

Original comments from Roger Longman:

Date: 05/23/2003 12:06:22

 

Am getting the suspicion that things may be turning around for biotech.

Have no understanding of investor mentality but there's been some

intriguing bits of news lately and I'm sensing (perhaps because my

sensors are largely focused inward)...change.

 

1)       Genentech's Avastin news.  Good for Genentech, but more

importantly, lots of biotechs have angiogenesis inhibitors in their

pipelines-and those projects have largely been written off because

angiogenesis inhibitors haven't shown great medical value...now it

appears that the value just might take a while to uncover.  But it's

there.

 

2)       Amgen's deal with Tularik.  Big deal; discovery focused--Amgen

buying a discovery capability in small molecules-and it's discovery that

investors are most scared of (which is why all the big deals have

focused on late-stage products, in which the discovery risk has largely

been bypassed).

 

3)       Some other bits of scattered good news: Novartis' 51%

acquisition of Idenix; Roche's deal with Maxygen on antivirals...all of

which point to the crying need Big Pharma has for biotech.  What's

interesting, however, is that they're not simply turning to biotech's

later-stage products, but to earlier stage and discovery programs. 

 

4)       Consolidation possibilities within biotech could also drive

share values.  Biotech is totally unconsolidated and likely to remain so

as long as market conditions remain as they are: no biotech that doesn't

already have strong cash flow (and there are very few of those) is

willing to buy a money-losing, cash-burning discovery operation (the

vast majority of biotechs today).  They might have been willing to buy

these companies at one point-when Pharmas were willing to do discovery

deals and an acquisition of an important technology-oriented company

might have helped accomplish such an alliance-but not now, when Pharmas

have shown themselves unwilling to do big-dollar discovery deals.

However, if some of the better financed later-stage biotechs can raise a

bunch of money now, they might buy some earlier-stage discovery

companies, which would drive up the value of the better independent

discovery companies.  Trickle down economics works in biotech, if

nowhere else.

 

In any event, this bears watching. 

 

 

Roger Longman

Managing Partner and Editor

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